17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy
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چکیده
منابع مشابه
17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy
BACKGROUND The accumulation and aggregation of alpha-synuclein in nerve cells and glia are characteristic features of a number of neurodegenerative diseases termed synucleinopathies. alpha-Synuclein is a highly soluble protein which in a nucleation dependent process is capable of self-aggregation. The causes underlying aggregate formation are not yet understood, impairment of the proteolytic de...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0008753